Pathology outlines peripheral t cell lymphoma, not. Lennert lymphoma ll is a lymphoepithelioid morphological variant of peripheral tcell lymphomanot otherwise specified ptclnos, clinically characterized by better prognosis if compared with other ptclnos. Lymphnode calcification in lennerts lymphoma the british. Transcriptional analysis of lennert lymphoma reveals a. We believe this to be the first report of this association. Lymphoepithelioid lymphoma lennerts lymphoma was first described as a special variant of hodgkins disease. A case of lennerts lymphoma with calcification seen in a mesenteric lymph node mass at presentation is described. Our results strongly suggest that lennerts lymphoma is a cd4positive t cell lymphoma.
Peripheral tcell lymphoma excluding anaplastic largecell. Frontiers transcriptional analysis of lennert lymphoma. It is also known as lymphoepithelioid lymphoma the peripheral tcell lymphoma or ptcl is a type of nodal or soft tissue lymphoma, which are generally restricted to lymph nodes and do not enter the bloodstream until later stages of the disease. Ii i ii ii i lennert s lymphoma presenting with clusters of cutaneous infection isaac zamora, m. Cleveland, oh we recently diagnosed and studied a case of lennert s lymphoma in a young black man who presented with a chronic pyoderma and multiple cutaneous infections of viral origin. Effective treatment of a peripheral tcell lymphoma. Effective treatment of a peripheral tcell lymphomalymphoepitheloid cell variant lennerts lymphoma refractory to chemotherapy with the cd52 antibody alemtuzumab. A patient with lennerts lymphoma malignant lymphoma with a high content of epithelioid histiocytes is described. Successful allogeneic stem cell transplantation for. Revising the historical collection of epithelioid cell. We determined that ptgcs can be seen simultaneously with lymphoma and.
Lennerts lymphoma presenting with clusters of cutaneous. A heterogeneous category of nodal and extranodal mature t cell lymphomas which do not correspond to any of the specifically defined entities of mature t cell lymphoma in the current classification who classification of tumours of haematopoietic and lymphoid tissues, 4th edition, lyon 2008. When treatment is required for lymphoma, one or more of the following therapies may be. Ptl is characterized by a heterogeneous cellular composition with small and large cells with an inflammarory background. This lesion is characterized by a high percentage of epithelioid and t cells and rarely. In total, lennert contributed over 300 scholarly papers and 4 textbooks to the medical literature during his working life. Older lymphoma classification systems include the rappaport system, which was used until the mid 1970s, 1 the kiel system, introduced in 1974, 2 and the national cancer institutes working formulation, introduced in the 1980s. Lennerts lymphoma synonyms, lennerts lymphoma pronunciation, lennerts lymphoma translation, english dictionary definition of lennerts lymphoma. Often used to denote malignant lymphoma, classifications of which are based on predominant cell type and degree of differentiation. Lymph node, mixedcellularity hodgkin lymphoma disease. By continuing to use our website, you are agreeing to our use of cookies. Histoplasma capsulatum was cultured from splenic tissue obtained at diagnostic laparotomy in a patient with lennert s lymphoma. The history of lymphoma classification and the 2017 revision german ott department of clinical pathology, robertboschkrankenhaus and dr. In both cases, the proliferation evolved in we use cookies to enhance your experience on our website.
Sa ss lymphoepithelioid cellular lymphoma lennerts. Lennert s lymphoma, or malignant lymphoma with a high content of epithelioid histiocytes, is an uncommon variant of nonhodgkins lymphoma. This report highlights the role of idiopathic immunosuppression in lymphoma patients. Full text get a printable copy pdf file of the complete article 3.
Lennerts lymphoma article about lennerts lymphoma by. We recently diagnosed and studied a case of lennerts lymphoma in a young black man who presented with a chronic pyoderma and multiple cutaneous infections of viral origin. Progressive transformation of germinal centers ptgcs is a benign disease of the lymph nodes that is rarely associated with hodgkin disease. The case is unique in that hepatosplenomegaly was the presenting feature, the diagnosis was made on bone marrow biopsy and the disorder appears to have run a benign course. Effective treatment of a peripheral tcell lymphoma lymphoepitheloid cell variant lennert s lymphoma refractory to chemotherapy with the cd52 antibody alemtuzumab. Lennerts lymphoma definition of lennerts lymphoma by the. It is suggested that mycologic cultures as well as. All cases showed rearrangement of the gene coding for the. Treatment options are based on the type and stage of lymphoma and the age and overall health of the patient. In this study, we investigated the transcriptional.
Additionally, the results suggest that a subgroup of ptclsu, distinct from aitl and including some cases denominated as alcl, may also be derived from t fh cells, although they develop along a distinct pathogenic pathway. In addition, lymphoepithelioid lennerts lymphoma was considered to represent a cytologic variant. To revise 25 cases selected from karl lennerts personal archive 21 and bologna and frankfurt registries four because of cytological similarities. Lymphoepithelioid lymphoma lennerts lymphoma is a monoclonal proliferation of helperinducer t cells. This provides strong evidence that lennerts lymphoma is a t. Lennert lymphoma ll, or the lymphoepithelioid variant of peripheral tcell lymphoma, is an uncommon entity which was first characterized in 1952 by karl. Malignant lymphomas other than hodgkins disease histology.
In joint discussions in 1974, the club worked out a new terminology that was acceptable to all members and will hopefully be acceptable to other pathologists. Lennerts lymphoma can be recognized by the presence of numerous epithelioid histiocytes usually grouped in small clusters. Lennerts lymphoma article about lennerts lymphoma by the. Pdf on jan 1, 2015, akhil kapoor and others published lennerts lymphoma a diagnostic dilemma. Peripheral t cell lymphomas with follicular t helper. Two cases of a recently described lymphoproliferative disorder called lennerts lymphoma are presented. Jan 28, 2014 a case of lennert s lymphoma with calcification seen in a mesenteric lymph node mass at presentation is described. Cleveland, oh we recently diagnosed and studied a case of lennerts lymphoma in a young black man who presented with a chronic pyoderma and multiple cutaneous infections of viral origin. The implication of these findings in relation to the nature of lennerts lymphoma are briefly discussed. Any of various malignant tumors that arise from the lymphocytic cells of the immune system. Lymphoepithelioid lymphoma lennert s lymphoma was first described as a special variant of hodgkins disease. Lennert s lymphoma can be recognized by the presence of numerous epithelioid histiocytes usually grouped in small clusters. Although well characterized as far as morphology and phenotype are concerned, very little is known regarding its molecular features. Since then, it has been called the kiel classification.
A patient with lennert s lymphoma malignant lymphoma with a high content of epithelioid histiocytes is described. Tcell lymphoma of thyroid gland with lennert type of. The lymphatic system is part of your bodys immune system. Diagnostic reed sternberg cells are usually found without difficulty in mixedcellularity hodgkin lymphoma. Lymphoepithelioid variant lennerts lymphoma is a distinct morphologic variant of peripheral tcell lymphoma that has numerous epithelioid histiocytes. The implication of these findings in relation to the nature of lennert s lymphoma are briefly discussed. Margarete fischerbosch institute of clinical pharmacology, stuttgart esmo perceptorship on lymphoma, lugano 2018. Treating nonhodgkin lymphoma american cancer society. Lennerts lymphoma with transformation to malignant. Lennert lymphoma is a rare type of nonhodgkin lymphoma that is a variant of peripheral tcell lymphoma. Lennert s lymphoma is a rare variant of peripheral tcell lymphoma ptcl not otherwise specified nos rich in epithelioid histiocytes. A distinct clinicopathologic entity and a form of socalled lennerts lymphoma.
A case of lennerts lymphoma journal of clinical pathology. This study aims to analyze the clinical, morphologic, and immunophenotypic profile of cases of lennert s lymphoma from our country and determines the utility of tcell receptor tcr gene rearrangement in the diagnosis. Lennert lymphoma ll, or the lymphoepithelioid variant of peripheral tcell lymphoma, is an uncommon entity which was first characterized in 1952 by karl lennert. The history of lymphoma classification and the 2017 revision. They are seen in this image as lighter pink areas in between clusters of small lymphocytes. Nodal peripheral t cell lymphoma unspecified surgical. The primary extranodal ptcl subtypes covered by the present guidelines comprise enteropathyassociated tcell lymphoma eatl, extranodal natural killertcell lymphoma enktcl, and hepatosplenic tcell lymphoma hstcl. For some types of lymphoma, if the disease is advanced but slowgrowing indolent, a waitandsee approach may be an option. Download fulltext pdf update on classification of lymphomas article pdf available in dental hypotheses 41. Non hodgkin lymphoma by dr tashi agarwal moderator. A heterogeneous category of nodal and extranodal mature t cell lymphomas which do not correspond to any of the specifically defined entities of mature t cell lymphoma in the current classification who classification of tumours of haematopoietic and. It is now commonly and eponymously called lennert s lymphoma. Lennerts lymphoma is a rare variant of peripheral tcell lymphoma ptcl not otherwise specified nos rich in epithelioid histiocytes. Expression of cxcl, a chemokine highly upregulated in.
Our recent report of expression of cxcl, a chemokine critical for germinal. The disease cannot be separated from the broad category of peripheral tcell lymphoma ptl. Mar 16, 2016 the rare entity of primary tcell lymphoma of thyroid gland may pose great diagnostic and therapeutic challenges to the pathologist and clinician. Peripheral tcell lymphoma blood american society of.
Peripheral tcell lymphoma ptcl is rare in most parts of the world. There are very few case and short series reports of these tumors describing their varied clinicopathologic features in english literature. Sa ss lymphoepithelioid cellular lymphoma lennerts lymphoma. Lennerts lymphoma is a rare variant of peripheral tcell lymphoma ptcl not otherwise specified nos. A 66yearold, previously well woman presented with a 2month history of loss of appetite, nausea, tiredness and weight loss. Lymphoma is a cancer that develops in the white blood cells lymphocytes of the lymphatic system.
Lymphoepithelioid cell lymphoma lennert lymphoma t cell lymphoma with high content of epithelioid lymphocytes. This study aims to analyze the clinical, morphologic, and immunophenotypic profile of cases of lennerts lymphoma from our country and determines the utility of tcell receptor tcr gene rearrangement in the diagnosis. Cytogenetic abnormalities indicate that lennert s lymphoma is of t cell origin. This study aims to analyze the clinical, morphologic, and immunophenotypic profile of cases of lennert. The rare entity of primary tcell lymphoma of thyroid gland may pose great diagnostic and therapeutic challenges to the pathologist and clinician. Lennert is also recognized for first describing a variant of peripheral tcell lymphoma in 1952, which he termed lymphoepithelioid lymphoma. Lennert s lymphoma is a rare variant of peripheral tcell lymphoma ptcl not otherwise specified nos. Histoplasma capsulatum was cultured from splenic tissue obtained at diagnostic laparotomy in a patient with lennerts lymphoma. The patient had no clinical features suggesting histoplasmosis, and the organism was not seen on histologic specimens. The aim of this study was to further characterize this tumour. Morphologically and immunophenotypically heterogeneous group of nodal t cell lymphomas that do not meet the diagnostic criteria of one of the other whodefined tcell lymphoma categories.
Lennert lymphoma ll is a lymphoepithelioid morphological variant of peripheral tcell lymphomanot otherwise specified ptclnos. All cases diagnosed as lennerts lymphoma during the period of january. Lennert lymphoma is a systemic tcell lymphoma that presents with cutaneous skin lesions roughly 10% of the time 739 it is also known as lymphoepithelioid variant of peripheral tcell lymphoma. We report a case of mature tcell lymphoma of thyroid in a 26 year old male, with unique pseudogranulomatous. Lymphoepithelioid lymphoma lennerts lymphoma is a monoclonal. It is suggested that mycologic cultures as well as histopathological examinations of surgical specimens be performed routinely in. It is suggested that mycologic cultures as well as histopathological examinations of surgical specimens be performed routinely in immunologically.
Histoplasmosis and lennerts lymphoma jama internal. Lennerts lymphoma, or malignant lymphoma with a high. Cytogenetic abnormalities indicate that lennerts lymphoma is of t cell origin. Lennerts lymphoma is a rare variant of peripheral tcell lymphoma ptcl. Peripheral t cell lymphomas with follicular t helper phenotype.
Follicular lymphoma is a common type of nhl, and occurs almost exclusively in adults. Lennerts lymphoma definition of lennerts lymphoma by. Pdf on jan 1, 2015, akhil kapoor and others published lennert s lymphoma a diagnostic dilemma. Kim h, jacobs c, warnke ra, dorfman rf 1978 malignant lymphoma with a high content of epithelioid histiocytes. Lennerts lymphoma is a rare variant of peripheral t. The strain reverted slowly to the yeast phase and was difficult. The name lennerts lymphoma has been applied to a form of malignant lymphoma with a high content of epithelioid histiocytes which was first described. Classification historically a mess 1940s gail and mallory 1950s rappaport 1970s lukescollins 1970s kiel 1982 working 1994 real 2001, 2008 who 2 3. Peripheral tcell lymphoma with follicular tcell markers. For personal accounts or managers of institutional accounts. Its important to weigh the benefits of each treatment option against the possible risks and side effects. This lesion is characterized by a high percentage of epithelioid and t cells and rarely contains the classical hodgkinsreedsternberg cells. Lennerts lymphoma diffuse mixed tcell ml with excessive histiocytes. Oct 20, 2011 peripheral t cell lymphomas with follicular t helper phenotype.
On 27 august 2012, karl lennert, emeritus professor of pathology at. The germinal center thelper cell has been proposed as the cell of origin for angioimmunoblastic tcell lymphoma. Lennerts lymphoma was first described as a special variant of hodgkins disease. Ii i ii ii i lennerts lymphoma presenting with clusters of cutaneous infection isaac zamora, m. Sep 10, 2019 lennert lymphoma ll is a lymphoepithelioid morphological variant of peripheral tcell lymphomanot otherwise specified ptclnos, clinically characterized by better prognosis if compared with other ptclnos. A 66yearold, previously well woman presented with a 2month history of. Lymphoepithelioid lymphoma lennert s lymphoma is a monoclonal proliferation of helperinducer t cells.
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